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Assessment, Vol. 8, No. 2, 127-143 (2001)
DOI: 10.1177/107319110100800202
© 2001 SAGE Publications

A New MMPI-Derived Indicator of Liability to Develop Schizophrenia: Evidence from the New York High-Risk Project

P. Kevin Bolinskey

Irving I. Gottesman

University of Virginia

David S. Nichols

Portland, OR

Barbara M. Shapiro

Simone A. Roberts

Ulla H. Adamo

New York State Psychiatric Institute

L. Erlenmeyer-Kimling

New York State Psychiatric Institute and Columbia University

A large body of research indicates that the liability to develop schizophrenia is largely genetically mediated, although phenotypic expression requires environmental triggers/insults and/or epigenetic and/or stochastic factors. In an effort to identify the precise environmental factors that precipitate a predisposition to schizophrenia, researchers have implemented a high-risk model-the prospective study of offspring born to schizophrenic parents. As it is difficult to ascertain exactly which of the "high-risk" participants will actually develop the disorder, we examined the validity of an experimental MMPI scale, Schizophrenia Proneness (SzP), and the Moldin-Gottesman psychometric index to identify such individuals. Results suggest that the SzP scale can be an effective predictor of schizophrenia-related psychoses. A revised psychometric index is offered for further study.

Key Words: Schizophrenia • MMPI • New York High-Risk Project • offspring of schizophrenics • genetics


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