This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Paulsen, J. S. Articles by Hospital, B. Search for Related Content PubMed Articles by Paulsen, J. S. Articles by Hospital, B. Social Bookmarking                         What's this?

Frontal Behavioral Syndromes in Cortical and Subcortical Dementia

University of California, San Diego San Diego Department of Veterans Affairs Medical Center

Julie C. Stout

Indiana University

Jody DeLaPena

University of California, San Diego

Ramon Romero

University of California, San Diego

Zeena Tawfik-Reedy

University of California, San Diego

Michael R. Swenson

University of California, San Diego

Janet Grace

Memorial Hospital of Rhode Island Brown University School of Medicine

Paul F. Malloy

Brown University School of Medicine

Butler Hospital

Brown University School of Medicine

The Frontal Lobe Personality Scale (FLOPS; Grace & Malloy, 1992) was administered to the caregivers of 51 patients with neurodegenerative disease to examine personality and behavioral features associated with prototypical "cortical" dementia (i.e., Dementia of the Alzheimer Type; DAT) and "subcortical" dementia (i.e., Huntington's disease; HD). The FLOPS is a 45-item behavior rating scale designed to identify three frontal syndromes: (a) apathy, (b) disinhibition, and (c) executive dysfunction.

Comparing subgroups of HD and DAT that were matched for age and dementia severity (ns = 12), the HD subgroup had higher FLOPS apathy ratings. Using all patients, FLOPS ratings were associated with traditional neuropsychological measures as well as a measure of everyday functioning.

Discriminant function analyses, accurately classified over 92% of the DAT patients and nearly 77% of the HD patients, which is consistent with the discriminative utility of other traditional neuropsychological tests. These data suggest that informant-based ratings of so-called "frontal lobe" behaviors may be a useful adjunct to current neuropsychological evaluations in an attempt to characterize personality changes that co-occur with neurodegenerative disease.

Assessment, Vol. 3, No. 3, 327-337 (1996)
DOI: 10.1177/1073191196003003012


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				D. I. Velligan, P. M. Diamond, J. Mintz, N. Maples, X. Li, J. Zeber, L. Ereshefsky, Y.-W. F. Lam, D. Castillo, and A. L. Miller The Use of Individually Tailored Environmental Supports to Improve Medication Adherence and Outcomes in Schizophrenia Schizophr Bull, May 1, 2008; 34(3): 483 - 493. [Abstract] [Full Text] [PDF]

				R. van Reekum, D. T. Stuss, and L. Ostrander Apathy: Why Care? J Neuropsychiatry Clin Neurosci, February 1, 2005; 17(1): 7 - 19. [Abstract] [Full Text] [PDF]

				J. C. Stout, R. E. Ready, J. Grace, P. F. Malloy, and J. S. Paulsen Factor Analysis of the Frontal Systems Behavior Scale (FrSBe) Assessment, March 1, 2003; 10(1): 79 - 85. [Abstract] [PDF]

				D. R. Royall, E. C. Lauterbach, J. L. Cummings, A. Reeve, T. A. Rummans, D. I. Kaufer, W. C. LaFrance Jr., and C. E. Coffey Executive Control Function: A Review of Its Promise and Challenges for Clinical Research. A Report From the Committee on Research of the American Neuropsychiatric Association J Neuropsychiatry Clin Neurosci, November 1, 2002; 14(4): 377 - 405. [Abstract] [Full Text] [PDF]

				T. M. Zawacki, J. Grace, R. Paul, D. J. Moser, B. R. Ott, N. Gordon, and R. A. Cohen Behavioral Problems as Predictors of Functional Abilities of Vascular Dementia Patients J Neuropsychiatry Clin Neurosci, August 1, 2002; 14(3): 296 - 302. [Abstract] [Full Text] [PDF]

				J S Paulsen, R E Ready, J M Hamilton, M S Mega, and J L Cummings Neuropsychiatric aspects of Huntington's disease J. Neurol. Neurosurg. Psychiatry, September 1, 2001; 71(3): 310 - 314. [Abstract] [Full Text] [PDF]

				J. Grace, J. C. Stout, and P. F. Malloy Assessing Frontal Lobe Behavioral Syndromes with the Frontal Lobe Personality Scale Assessment, September 1, 1999; 6(3): 269 - 284. [Abstract] [PDF]

				M. L. Levy, J. L. Cummings, L. A. Fairbanks, D. Masterman, B. L. Miller, A. H. Craig, J. S. Paulsen, and I. Litvan Apathy Is Not Depression J Neuropsychiatry Clin Neurosci, August 1, 1998; 10(3): 314 - 319. [Abstract] [Full Text]